Lab news
2024
At the Annual MSK IGO open house, our crew dressed up as Rick and Morty’s (and portals). We were voted the funniest group costume–that means a free party! Thanks IGO!!
party
The lab receives its first independent grant to study the Human Virome from the National Center for Complementary and Integrative Health and the NIH Office of Director. This support will allow the lab to pursue its most ambitious research related to human viruses. Stay tuned for more!
Congrats to Erin for winning the People’s Choice Award at the MSKCC postdoc slam competition. Erin presented a verbal summary of her work studying how the same infections can influence individuals differently, including HHV-6 that can be transmitted through the germline.
The first review paper from the lab is out in Trends in Biotechnology that explores key concepts in technology development for droplet-based single-cell assays. Congratulations to Arthur for leading the writing and framing this article! You can find the manuscript online here.
A preprint summarizing potential biases and artifacts in single-cell mtDNA sequencing data is posted on bioRxiv. Check out Caleb’s thread for more information.
A collaborative review article written with the Leif Ludwig Lab is online today at Nature Genetics. The review summaries the rapid deveopment of new technologies for single-cell genomics that have specifically informed a new era of studying mitochondrial genetics. Let us know what you think!
Emma Tran joints the lab for the summer as the first ever intern in the lab! Emma joints us as part of the MSKCC CBSP for undergraduate students. Welcome!
The lab takes part in the U54 Tumor Ecosystems symposium at MSK. Caleb shared the lab’s work on PERFF-seq.
Erin Cumming, PhD, joins the group as the second postdoctoral fellow. Erin completed her PhD at the Cancer Research Scotland Institute (formerly the CRUK Beatson Institute). Welcome Erin!
The lab debuts its work on PERFF-seq at Single Cell Genomics Day 2024 via a YouTube livestream. Thank you to Rahul for the invitation to present!
The lab presents its work in beautiful Cancun, Mexico at the 2nd Annual Probing Human Disease with Single Cell Technologies Conference. Thank you to the organizers for inviting us back to present!
The lab welcomes Sherry Nyeo, Jonathan Levine, and Hoyin Chu as its first rotation students from the Cornell Tri-I CBM program!
2023
Laura Kida and Josch Hsieh join the group! Laura is studying for her MD in Berlin, and Josch is currently a PhD candidate in Leif Ludwig’s group. Both will be in the lab for several months to help establish new directions as they study for their theses. Welcome!
Our paper describing HHV-6 reactivation in T cells, including therapeutic CAR T cells is online today. See Caleb’s tweetorial here and coverage from STAT News here.
Arthur Chow, PhD, joins the group as the lab’s first postdoctoral fellow! Arthur completed his PhD at Icahn School of Medicine at Mount Sinai. He brings a wealth of experimental expertise and technical support from Kinzo, Ono, and Zuka. Welcome Arthur!
Caleb participates in the SITC Sparkathon 2023 emerging leaders symposium in Chicago, IL. While at the conference, he received a Distinguished Young Investigator award from the organizers of the class. We’re excited to participate in the main conference in San Diego this November!
Benan Nalbant (Senior Research Technician) joins the lab as the first member! Benan joins the lab after spending years at CSHL developing cell models to study transcription factor dependencies in cancer. Welcome Benan!
The lab officially opens today at Memorial Sloan Kettering. Our official institute page can be found here. Come see our awesome window views out of the 11th floor of the Zuckerman Research Center on 68th Ave in NYC!
The lab joins the Human Cell Atlas General Meeting in Toronto, Canada. We are grateful to the organizers for the invitation to present!
Our work resolving purifying selection of pathogenic mtDNA in specific immune cells has been published in Nature Genetics! Check out our tweetorial here and a News and Views piece from colleagues at the Wellcome Centre for Mitochondrial Research summarizing the key points of this work.
Caleb is named an Emerging Leader in Computational Oncology by Memorial Sloan Kettering Cancer Center! Awardees took place in a two day symposium in New York hosted by faculty in the Computational Oncology program.
A new preprint outlining a potential role for synonymous variation in the mitochondrial genome just dropped on bioRxiv! In brief, we provide new lines of evidence that synonymous variation in the mitochondrial genome may have a functional role due ot the limited tRNA pool requiring wobble-dependent translation. Check out a digest of the work in our twitter thread!
Supported by the group’s K99/R00 Pathway to Independence Award, the lab attends the NHGRI Research Training and Career Development Annual Meeting in Salt Lake City, Utah.